7 Best Supplements For Histamine Intolerance

Trying to find supplements for histamine intolerance that actually work?

No worries. Today, I'll tell you about the 7 best supplements for histamine intolerance that are all-natural and scientifically proven to ease your symptoms.

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What the Histamine is Going on?

They are one of the good guys in the complex cocktail that make up your body’s immune system – helping you gear up to fight a bad flu or infection. Yes, we’re talking about histamines – those ‘bonafide hustlers’ who make you itch, swell or even erupt in red patches, whatever it takes to get the bad boys out of your system asap.

Unfortunately, sometimes, an excessive amount of histamines can make your body react like a bouncer who keeps out even the invited guests to the party - causing your body to respond violently to what are otherwise harmless triggers. If you have ever wiped a bookshelf covered in dust only to start sneezing violently, or eaten high histamine foods that don't cooperate with your system and broken into a bout of rashes, you'll know what I'm talking about.

As you must know if you are a regular reader to this blog, I believe the right food choices can prevent a whole lot of health conditions and imbalances in the body, and histamine intolerance is no different. A balanced diet with low histamine foods can certainly help reduce symptoms of histamine intolerance. However, to kick start your maladjusted immune system, here are some tried and tested supplements for histamine intolerance that will help you bid goodbye to your histamine intolerance symptoms and say hello to an easier daily life.

Each of these supplements for histamine intolerance was carefully selected through research. They have been tried and tested for their efficacy in histamine intolerance, and are backed by numerous scientific studies which I've cited throughout.

Along with a nutritious, low histamine diet, the right supplements for histamine intolerance can go a long way in alleviating symptoms. Be sure to use a combination of my free low histamine diet, along with the supplement recommendations.

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As a histamine intolerance expert, here are my top supplement recommendations to help you say goodbye to the itches, sniffles and other body-wide symptoms that come along with with histamine intolerance.

7 Best Supplements for Histamine Intolerance

1. The Right Probiotic
It should be a more wide-spread word of caution that when selecting supplements for histamine intolerance, probiotics are one of the most important to pay attention to. It is absolutely essential that care is taken to choose the right strains, as the wrong combination of bacteria can actually aggravate symptoms!

This is because many “beneficial” bacteria actually produce histamine. This production is natural and, in a healthy, non-histamine-intolerant individual, the body will degrade this histamine easily.

However, in a histamine intolerant individual, it’s important to ensure you’re not adding any histamine-producing bacteria into your system and, instead, balancing your microbiome using histamine-friendly probiotics.

In order to avoid aggravating symptoms, using a tailored, low-histamine probiotic would be the best starting supplement for histamine intolerance, as it will help to balance your gut bacteria using particular strains of probiotics that are histamine-friendly.

I use a low histamine probiotic that combines six non-dairy, stomach acid resistant strains of beneficial bacteria that are, most importantly, low histamine. These probiotics have proven effective effective in numerous studies [1-4]. My clients using a low histamine probiotic have seen great results through both oral and rectal administration via probiotic enemas.

For a more detailed explanation on selecting the perfect, histamine-friendly probiotic, check out this article I wrote on probiotics for histamine intolerance.

2. Vitamin C
Here's something you've probably heard from your mother before: a daily dose of Vitamin C can really help boost the body’s immune system. This notion doesn’t simply come from the wisdom of old wives’ tales - it’s corroborated by science.

Numerous studies have shown that intake of Vitamin C as a supplement for histamine intolerance can reduce the symptoms of histamine intolerance itself [5]. Additionally, Vitamin C is a powerful antioxidant and provides numerous additional benefits to the body, including preventing biological ageing which is associated with disease status later in life.

Keep in mind that citrus fruits, some of the highest common sources of vitamin C, are actually restricted on a low histamine diet, which may make meeting the daily requirement even harder. In this case, supplementation can be both practical and therapeutic.

3. Quercetin
Quercetin, a plant pigment found in many proclaimed superfoods, has been shown to be an effective supplement for histamine intolerance by directly blocking the release of histamine from mast cells. Mast cells contain molecules called mediators (histamine is one such mediator) which are secreted when the cells are triggered.

Studies have shown quercetin to display both anti-inflammatory and anti viral properties. It works more effectively with a supplement which contains bromelain (a compound found in pineapples) as well [6].

4. Bromelain
Bromelain is a phytochemical compound found in high concentration in the stem of pineapples. In other words, it’s a common mistake that eating pineapple chunks will provide a sufficient source of this beneficial compound!

Bromelain has been used in traditional medicine systems across the world for centuries and, recently, science has begun to dive into the evidence behind this "miracle compound".

According to studies, bromelain has shown to be effective in the treatment of numerous histamine-associated symptoms, while simultaneously improving absorption of certain compounds in the gut [6,7].

5. Stinging nettles
Stinging nettles, or Urtica dioica, has been shown to work better in blind tests than a placebo to reduce symptoms of histamine intolerance [8]. Let us see what happens behind the screen when the body ingests Urtica dioica…

Interestingly, the stinging hairs on the leaves of the species are rich in serotonin (5-hydroxytryptamine) and acetylcholine. Through the process of freeze-drying, Urtica dioica is able to preserve its anti-allergen properties and work similar to existing antihistamines in the market.

A randomized, double-blind study using 300 mg freeze-dried Urtica dioica to treat patients with allergic rhinitis found that 69 of patients who participated in the study rated it as more effective than a placebo [9]. Another 58 percent felt it was effective in relieving their symptoms.

It's interesting that this treatment has been effective, despite the fact that the stinging hairs themselves contain histamine. The reason for this, is because histamine has the ability to work as a local regulator to modulate immune response, therefore resulting in reduced symptoms!


6. N-acetyl cysteine
N-acetyl cysteine is an important supplement for histamine intolerance, as it has shown to be responsible for potentiating inhibitory effects of mast cells on histamine release. In other words, N-acetyl cysteine acts as an assistant for maximizing the effect of other supplements that are used to reduce histamine release [10].

This assistance can produce profound effects, as an increased release of histamine from mast cells is one of the primary causes of histamine intolerance, thus indicating that N-acetyl cysteine can relieve symptoms by targeting the root cause of histamine intolerance, rather than the symptom itself.

7. Natural D-Hist
Natural D-Hist is a true superhero when it comes to supplements for histamine intolerance, as its compounds have all shown promising results in testing.

The all-natural supplement contains stinging nettles leaf, N-acetyl cysteine, quercetin, bromelain and vitamin C, all of which have been demonstrated to be top superpowers for reducing histamine-associated symptoms [1-10].

In other words, Natural D-Hist combines all of the best histamine-healing remedies into one single supplement of perfectly proportioned dosages for maximum symptom relief.

The compounds in D-Hist have been shown to be very effective in treating sinus allergies and common symptoms of histamine intolerance. Unlike over-the-counter medications, this natural supplement does not cause drowsiness and, has been reported by clients to start seeing noticeable improvements in as little as 10 days.

Natural D-Hist is by far my #1 recommended supplement for histamine intolerant clients because they can actually feel the difference, rather than being unsure if it’s working or not. It has even been referred to by my clients as a “miracle in a bottle” and a “wonder-drug!”

  1. Yang, P., Yang, G. and Liu, Z. (2013). Treatment of allergic rhinitis with probiotics: An alternative approach. North American Journal of Medical Sciences, 5(8), p.465. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3784923/
  2. Ishida, Y., Nakamura, F., Kanzato, H., Sawada, D., Hirata, H., Nishimura, A., Kajimoto, O. and Fujiwara, S. (2005). Clinical Effects of Lactobacillus acidophilus Strain L-92 on Perennial Allergic Rhinitis: A Double-Blind, Placebo-Controlled Study. Journal of Dairy Science, 88(2), pp.527-533. https://www.ncbi.nlm.nih.gov/pubmed/15653517/
  3. Kawase, M., He, F., Kubota, A., Hiramatsu, M., Saito, H., Ishii, T., Yasueda, H. and Akiyama, K. (2009). Effect of fermented milk prepared with two probiotic strains on Japanese cedar pollinosis in a double-blind placebo-controlled clinical study. International Journal of Food Microbiology, 128(3), pp.429-434. https://www.ncbi.nlm.nih.gov/pubmed/18977549
  4. Ouwehand, A., Nermes, M., Collado, M., Rautonen, N., Salminen, S. and Isolauri, E. (2009). Specific probiotics alleviate allergic rhinitis during the birch pollen season. World Journal of Gastroenterology, 15(26), p.3261. https://www.ncbi.nlm.nih.gov/pubmed/19598302
  5. Hemilä, H. (2014). The effect of vitamin C on bronchoconstriction and respiratory symptoms caused by exercise: a review and statistical analysis. Allergy, Asthma & Clinical Immunology, 10(1), p.58. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4363347/
  6. Pavan, R., Jain, S., Shraddha and Kumar, A. (2012). Properties and Therapeutic Application of Bromelain: A Review. Biotechnology Research International, 2012, pp.1-6 https://www.ncbi.nlm.nih.gov/pubmed/23304525
  7. Heinicke, R., Van der Wal, L. and Yokoyama, M. (1992). Effect of bromelain (Ananase) on human platelet aggregation. Experientia, 28(7), pp.844-5. https://www.ncbi.nlm.nih.gov/pubmed/4658882
  8. Li, Y., Yao, J., Han, C., Yang, J., Chaudhry, M., Wang, S., Liu, H. and Yin, Y. (2016). Quercetin, Inflammation and Immunity. Nutrients, 8(3), p.167. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4808895/
  9. Thornhill, S. and Kelly, A. (2000). Natural Treatment of Perennial Allergic Rhinitis. Alternative Medicine Review, 5(5), pp.448-454. https://www.altmedrev.com/publications/5/5/448.pdf
  10. Masini, E., Di Bello, M., Pistelli, A., Raspanti, S., Gambassi, F., Mugnai, L., Lupini, M. and Mannaioni, P. (1994). Generation of nitric oxide from nitrovasodilators modulates the release of histamine from mast cells. J Physiol Pharmacol., 45(1), pp.41-53. https://www.ncbi.nlm.nih.gov/pubmed/7519083

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